1. Which of the following clinical interventions provides the highest mortality benefit?
1. Starting a diabetic with acute coronary syndrome on aspirin, statin, beta blocker and ACE inhibitor
2. Starting a diabetic with stable angina on statins and aspirin
3. Starting a diabetic with microalbuminuria on statins and ACE inhibitors
4. Adding aspirin and statin to a diabetic who is otherwise healthy

Answer: The answer is (a). Adding aspirin, statins, beta blockers and ACE Inhibitors provide definite mortality benefits. The evidence for mortality benefits in diabetics with chronic stable angina is available but not as strong as that for acute coronary syndrome. The other two choices do provide beneficial effects but not in terms of absolute mortality.