1. The following statement about statin therapy is true:
1. Serum LDL level acts as an index for primary prevention of CAD with statins
2. Serum CRP level acts as an index for primary prevention of CAD with statins
3. Serum homocysteine level acts as an index for primary prevention of CAD with statins
4. Serum Lp(a) acts as an index for primary prevention of CAD with statins

Answer: Some studies showed that statins had benefits even in patients with normal to low lipid levels. The AFCAPS/TexCAPS study looked into the predicitive value of serum CRP levels in assessing prevention of coronary artery disease. It was shown that Statin therapy may be effective in the primary prevention of coronary events among subjects with relatively low lipid levels but with elevated levels of C-reactive protein. Therefore CRP is a more sensitive prognostic index during the treatment with statins.