- A 67 years old lady was admitted to the coronary care unit with unstable angina. She was
wheeled to the cath lab and her coronary angiogram showed a 90% block in the LAD. Other
coronary vessels were not blocked significantly. She underwent a percutaneous balloon
angioplasty and was wheeled back to the floors. She recovered well and was preparing for a
discharge. She was previously on Metformin for her diabetes and fibrate for her raised
triglycerides. At this point what modification would be required in her prescription:
- Stop the fibrate and start her on Atorvastatin 40 mg daily
- Increase the dose of her fibrate for more aggressive lipid lowering.
- Stop the metformin and start her on glimepiride
- Start her on amlodipine for heart protection
Answer: The only important change that is required in her prescription is to start her
on a statin. In diabetics statins have been shown to have significant benefits with
secondary prevention of coronary artery disease. Increasing the dose of fibrates does not
have a similar effect.
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