Identify the incidence of hypercoagulable states
Explanation
The commonest Hyper-coagulation problem is Hereditary resistance of factor 5 to the anti coagulant effect of Protein C(Factor 5 leiden). It is typically associated with DVT in pregnant ladies and in those on OCPs.
Lupus anticoagulant is also tested on in the boards.
The typical events in Lupus anticoagulant patients are:
Other entities to think about are Deficiency of protein C or S. These are also associated with warfarin induced skin necrosis (this is an ischemic state that is brought on by warfarin. warfarin stops the formation of coagulation factors and other Vit K dependant stuff in the liver. Protein C & S are also Vit K dependant. the ones that have the shortest half life will get depleted the fastest. These are Protein C & S. They are actually natural anticoagulants and their disappearance leaves the body in a hyper-coagulable state that clots off vessels in the skin and causes this necrosis).
Other defects are anti-thrombin 3 deficiency, lupus anticoagulant.